Sréter L, Fehér J
Second Department of Medicine, Semmelweis University Medical School, Budapest.
Ther Hung. 1991;39(4):159-66.
Interferons are currently the most widely used biological response modifiers. They are of high clinical value in haematological malignancies (chronic myelogenous leukaemia, multiple myeloma, non-Hodgkin lymphoma), in solid tumours (malignant melanoma, hypernephroma, pancreas neoplasms, carcinoid tumours, Kaposi's sarcoma, glioma, in ovarium, cervix and bladder carcinoma, and in basalioma) and in infectious diseases (chronic hepatitis B, chronic non-A/non-B hepatitis, chronic delta hepatitis, AIDS, Papova virus and Rhinovirus infections, leishmaniasis, leprosy) and some other conditions. Although the mechanism of action of interferons has not been explained in every detail these agents are promising therapeutic means in a number of diseases.
干扰素是目前应用最广泛的生物反应调节剂。它们在血液系统恶性肿瘤（慢性粒细胞白血病、多发性骨髓瘤、非霍奇金淋巴瘤）、实体瘤（恶性黑色素瘤、肾细胞癌、胰腺肿瘤、类癌肿瘤、卡波西肉瘤、神经胶质瘤、卵巢癌、宫颈癌和膀胱癌以及基底细胞瘤）以及传染病（慢性乙型肝炎、慢性非甲/非乙型肝炎、慢性丁型肝炎、艾滋病、乳头多瘤空泡病毒和鼻病毒感染、利什曼病、麻风病）和其他一些病症中具有很高的临床价值。尽管干扰素的作用机制尚未完全阐明，但这些药物在许多疾病中是很有前景的治疗手段。
