Putzki H, Hafner O
Klinik und Poliklinik für Allgemeinchirurgie, Medizinischen Hochschule Hannover.
Gastroenterol J. 1991;51(3-4):104-7.
In a group of 80 patients with colorectal cancer and a control group of 91 persons and in 15 patients with acute diverticulitis of the sigmoid colon acid alpha-1-glycoprotein (AGP) and alpha-1-antitrypsin (AAT) were measured. The median of AAT in the carcinoma group was 3.34 g/l, in the control group 2.39 g/l. AGP was in the carcinoma group 1.19 g/l, in the control group 0.79 g/l. Both differences are significant. The sensitivities of AGP and AAT were compared with the sensitivities of CEA and CA 19/9 using ROC-curves. AAT and AGP have a distinctly lower sensitivity than CEA, but only on the basis of a high specificity of 95%. In the region of lower specificities AAT has the highest sensitivity. Therefore, the sensitivity of CEA for colorectal carcinoma is not reached by AAT and AGP, when a high specificity of the test is required. The relevance of AAT and AGP determinations is further reduced because in the diverticulitis group the levels were as high as in the carcinoma group.
对80例结直肠癌患者、91名对照者以及15例乙状结肠急性憩室炎患者测定了酸性α-1-糖蛋白（AGP）和α-1-抗胰蛋白酶（AAT）。癌组AAT的中位数为3.34 g/l，对照组为2.39 g/l。癌组AGP为1.19 g/l，对照组为0.79 g/l。两者差异均有统计学意义。采用ROC曲线比较了AGP和AAT与癌胚抗原（CEA）和CA 19/9的敏感性。AAT和AGP的敏感性明显低于CEA，但仅基于95%的高特异性。在较低特异性区域，AAT具有最高的敏感性。因此，当要求检测具有高特异性时，AAT和AGP未达到CEA对结直肠癌的敏感性。由于憩室炎组的水平与癌组一样高，AAT和AGP测定的相关性进一步降低。
