Formanowicz Dorota, Sackmann Andrea, Formanowicz Piotr, Błazewicz Jacek
Department of Clinical Biochemistry, Poznań University of Medical Sciences, Grunwaldzka 6, Poznań, Poland.
J Biomed Inform. 2007 Oct;40(5):476-85. doi: 10.1016/j.jbi.2006.12.001. Epub 2006 Dec 19.
The body iron homeostasis is a not fully understood complex process. Despite the fact that some components of this process have been described in the literature, the complete model of the whole process has not been proposed. In this paper a Petri net based model of the body iron homeostasis is presented. Recently, Petri nets have been used for describing and analyzing various biological processes since they allow modeling the system under consideration very precisely. The main result presented in the paper is twofold, i.e., an informal description of the main part of the whole iron homeostasis process is described, and then it is also formulated in the formal language of Petri net theory. This model allows for a possible simulation of the process, since Petri net theory provides a lot of established analysis techniques.
机体铁稳态是一个尚未被完全理解的复杂过程。尽管该过程的一些组成部分已在文献中有所描述，但整个过程的完整模型尚未被提出。本文提出了一种基于Petri网的机体铁稳态模型。最近，Petri网已被用于描述和分析各种生物过程，因为它们能够非常精确地对所考虑的系统进行建模。本文给出的主要成果有两个方面，即对整个铁稳态过程主要部分进行了非正式描述，然后还用Petri网理论的形式语言进行了表述。由于Petri网理论提供了许多成熟的分析技术，该模型使得对该过程进行可能的模拟成为了现实。
