口服和局部用莫西沙星在人体玻璃体内的渗透情况。

Vitreal penetration of oral and topical moxifloxacin in humans.

作者信息

Fuller Jeffrey J, Lott McGregor N, Henson Nathanael M, Bhatti Asmaa A, Singh Harinderjit, McGwin Gerald, Marcus Dennis M

机构信息

Department of Ophthalmology & Visual Science, University of Iowa, Iowa City, Iowa, USA.

出版信息

Am J Ophthalmol. 2007 Feb;143(2):338-40. doi: 10.1016/j.ajo.2006.09.023. Epub 2006 Oct 23.

DOI:10.1016/j.ajo.2006.09.023

PMID:17258525

Abstract

PURPOSE

To investigate the vitreal penetration of moxifloxacin after oral and topical administration.

DESIGN

Prospective, nonrandomized clinical trial.

METHODS

Twenty-four patients were assigned to one of four dosing groups: control (n = 3), which received no medication; oral (n = 8), which received two 400 mg oral doses of moxifloxacin before surgery; topical (n = 8), which received one drop of topical moxifloxacin 0.5% every 15 minutes for the hour preceding surgery; and combined (n = 5), which received two 400 mg oral doses and one drop of topical moxifloxacin 0.5% hourly for 18 hours prior to surgery. Vitreous samples were obtained and analyzed.

RESULTS

Control, below quantifiable levels; oral, 1.553 +/- 0.33 microg/ml; topical, 0.027 microg/ml; and combined, 2.219 +/- 0.71 microg/ml. One topical patient developed postoperative endophthalmitis.

CONCLUSIONS

In contrast to topical moxifloxacin, oral moxifloxacin achieves significant levels in the noninflamed human vitreous.

摘要

目的

研究口服和局部应用莫西沙星后在玻璃体中的渗透情况。

设计

前瞻性、非随机临床试验。

方法

24例患者被分配到四个给药组之一：对照组（n = 3），未接受任何药物治疗；口服组（n = 8），在手术前口服两次400mg莫西沙星；局部应用组（n = 8），在手术前1小时每隔15分钟局部应用一滴0.5%莫西沙星；联合应用组（n = 5），在手术前18小时口服两次400mg莫西沙星并每隔1小时局部应用一滴0.5%莫西沙星。获取玻璃体样本并进行分析。