眼压正常的慢性原发性闭角型青光眼患者的中央角膜厚度与视野进展
Central corneal thickness and visual field progression in patients with chronic primary angle-closure glaucoma with low intraocular pressure.
作者信息
Hong Samin, Kim Chan Yun, Seong Gong Je, Hong Young Jae
机构信息
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Am J Ophthalmol. 2007 Feb;143(2):362-3. doi: 10.1016/j.ajo.2006.09.038. Epub 2006 Oct 19.
PURPOSE
To determine the association of central corneal thickness (CCT) and visual field progression in patients with chronic primary angle-closure glaucoma (CPACG) with low intraocular pressure (IOP).
DESIGN
Retrospective, comparative case series.
METHODS
A total of 163 eyes with CPACG and sustained IOP <18 mm Hg were included. Initial and three-year after mean deviation (MD) on Humphrey field analyzer and CCT with ultrasonic pachymetry were recorded. On the basis of the CCT value, the sample was split in two groups (group 1 <540 microm; group 2 > or =540 microm).
RESULTS
Mean CCT was 525.8 +/- 11.6 microm in group 1 and 574.4 +/- 24.0 microm in group 2. There was no significant difference for initial MD (P = .979), but a significant difference was found between two groups for follow-up MD (P = .023).
CONCLUSIONS
Patients with CPACG with a thinner cornea are at greater risk for visual field progression even if they maintain a low IOP after treatment.
目的
确定慢性原发性闭角型青光眼（CPACG）且眼压较低（IOP）患者的中央角膜厚度（CCT）与视野进展之间的关联。
设计
回顾性、比较性病例系列研究。
方法
共纳入163例CPACG且持续性眼压<18 mmHg的患眼。记录Humphrey视野分析仪上的初始平均偏差（MD）和三年后的MD，以及超声测厚法测量的CCT。根据CCT值，将样本分为两组（第1组<540微米；第2组≥540微米）。
结果
第1组平均CCT为525.8±11.6微米，第2组为574.4±24.0微米。初始MD无显著差异（P = 0.979），但两组随访MD有显著差异（P = 0.023）。
结论
CPACG且角膜较薄的患者，即使治疗后眼压维持在较低水平，视野进展的风险也更高。
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