Papadia M, Sofianos C, Iester M, Bricola G, Mete M, Traverso C E
Centro di Ricerca Clinica e Laboratorio per il Glaucoma e la Cornea, Clinica Oculistica, DiNOG, University of Genova, Azienda Ospedaliera Universitaria San Martino, Genova, Italy.
Eye (Lond). 2007 Jul;21(7):943-7. doi: 10.1038/sj.eye.6702350. Epub 2006 Apr 28.
To verify whether there was a significant correlation between central corneal thickness (CCT) and visual field damage in patients with primary open angle glaucoma (POAG).
A total of 99 eyes with POAG were consecutively recruited. Patients were classified as glaucomatous based on visual field and optic nerve head damage. All underwent applanation tonometry, Humphrey perimetry, and measurement of CCT with ultrasonic pachymetry. Based on CCT value, the sample was split at the mode in two groups (group 1<535 microm, n=49; group 2>or=535 microm, n=50).
Entire cohort: mean CCT 554 microm+/-45.03; mean deviation (MD) -6.68 dB+/-7.32; pattern standard deviation (PSD) 5.33+/-3.75; intraocular pressure (IOP) 17.91+/-4.16 mmHg with treatment. Group 1: CCT was 504.8 microm+/-30.8; MD -9.01 dB+/-8.72; PSD 6.38+/-3.99; IOP 18.02 mmHg+/-4.66. Group 2: mean CCT 574.6 microm+/-35.03; MD -4.39 dB+/-4.70; PSD 4.25+/-3.19; IOP 17.79 mmHg+/-3.57. A significant difference was found between the two groups for both MD and PSD. Linear regression analysis showed a significant correlation between CCT and PSD (P<0.001).
Our data show that patients with a thinner cornea had a worse MD and PSD. As a thinner CCT causes an underestimation of the true IOP, there may be a delay in the diagnosis of POAG or an inadequate estimate of the clinical course despite apparently desirable IOP applanation readings.
验证原发性开角型青光眼（POAG）患者的中央角膜厚度（CCT）与视野损害之间是否存在显著相关性。
连续招募99只POAG患眼。根据视野和视神经乳头损害情况将患者分类为青光眼患者。所有患者均接受压平眼压测量、Humphrey视野检查以及用超声测厚仪测量CCT。根据CCT值，以中位数为界将样本分为两组（第1组＜535微米，n = 49；第2组≥535微米，n = 50）。
整个队列：平均CCT为554微米±45.03；平均偏差（MD）为 -6.68 dB±7.32；模式标准差（PSD）为5.33±3.75；治疗后眼压（IOP）为17.91±4.16 mmHg。第1组：CCT为504.8微米±30.8；MD为 -9.01 dB±8.72；PSD为6.38±3.99；IOP为18.02 mmHg±4.66。第2组：平均CCT为574.6微米±35.03；MD为 -4.39 dB±4.70；PSD为4.25±3.19；IOP为17.79 mmHg±3.57。两组之间在MD和PSD方面均存在显著差异。线性回归分析显示CCT与PSD之间存在显著相关性（P＜0.001）。
我们的数据表明，角膜较薄的患者MD和PSD更差。由于较薄的CCT会导致对真实眼压的低估，因此尽管眼压压平测量读数看似理想，但POAG的诊断可能会延迟或对临床病程的评估不足。
