Pagnini C, Cominelli F
Department of Digestive and Liver Disease, II School of Medicine, La Sapienza University, Rome, Italy.
Dig Liver Dis. 2006 Dec;38 Suppl 2:S270-3. doi: 10.1016/S1590-8658(07)60008-5.
In recent years, novel insights have been made into the role of bacterial microflora in health and disease. Commensal flora manipulation by probiotic bacteria has been investigated in human and experimental inflammatory bowel disease (IBD). In particular, animal models of IBD offer the opportunity to address important issues regarding indication, therapeutic efficacy and mechanism of action of the probiotic bacteria. Despite the appealing results of many published studies, fundamental questions still remain unanswered. Further studies on appropriate animal models are needed in order to better clarify our knowledge about probiotic bacteria and their potential application as a valid therapeutic option in IBD patients.
近年来，人们对细菌微生物群在健康和疾病中的作用有了新的认识。益生菌对共生菌群的调控已在人类和实验性炎症性肠病（IBD）中得到研究。特别是，IBD动物模型为解决有关益生菌的适应症、治疗效果和作用机制等重要问题提供了机会。尽管许多已发表的研究结果很有吸引力，但一些基本问题仍未得到解答。需要对合适的动物模型进行进一步研究，以便更好地阐明我们对益生菌及其作为IBD患者有效治疗选择的潜在应用的认识。
