人源化小鼠：现状与展望。
Humanized mice: current states and perspectives.
机构信息
Institut Pasteur, Unité de Biologie des Populations Lymphocytaires, CNRS URA 1961, 25 rue du Dr Roux, 75724 Paris Cedex 015, France.
出版信息
Immunol Lett. 2012 Aug 30;146(1-2):1-7. doi: 10.1016/j.imlet.2012.03.009. Epub 2012 Apr 9.
PMID:22507217
Abstract
The development of chimeric mice bearing the components of a human immune system to serve as animal models for "human" diseases has been the goal of many years of research. In this review we will discuss the latest advances in this field, their remaining shortcomings and challenges to the generation of new models of mouse/human chimeras.
摘要
多年来，研究的目标一直是开发携带人类免疫系统成分的嵌合小鼠作为“人类”疾病的动物模型。在这篇综述中，我们将讨论该领域的最新进展、它们仍存在的缺点以及生成新型小鼠/人类嵌合体模型的挑战。
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