使用CoCl₂·6H₂O、二(二苯基膦基)乙烷(dppe)和锌，按需生成一种由未活化腈和α,ω-二炔合成吡啶的高效催化剂。
On-demand generation of an efficient catalyst for pyridine formation from unactivated nitriles and alpha,omega-diynes using CoCl2-6H2O, dppe, and Zn.
作者信息
Kase Kouki, Goswami Avijit, Ohtaki Kazuhiko, Tanabe Emi, Saino Naoko, Okamoto Sentaro
机构信息
Department of Material & Life Chemistry, Kanagawa University, 3-27-1 Rokkakubashi, Yokohama 221-8686, Japan.
出版信息
Org Lett. 2007 Mar 1;9(5):931-4. doi: 10.1021/ol070037p. Epub 2007 Jan 30.
[reaction: see text] A highly practical, general method for catalytic formation of substituted pyridines from a variety of unactivated nitriles and alpha,omega-diynes is given. The reactions which were catalyzed by 5 mol % of dppe/CoCl2-6H2O in the presence of Zn powder (10 mol %) could proceed at rt to approximately 50 degrees C with high functional compatibility and regioselectivity.
[反应：见正文] 给出了一种从各种未活化腈和α,ω-二炔催化形成取代吡啶的高度实用的通用方法。在锌粉（10 mol%）存在下，由5 mol%的dppe/CoCl₂·6H₂O催化的反应可以在室温至约50℃下进行，具有高官能团兼容性和区域选择性。
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