通过α,β-不饱和酰基自由基在胺氮上的自由基取代反应合成内酰胺。

Synthesis of lactams by radical substitution reaction of alpha,beta-unsaturated acyl radicals at amine nitrogen.

作者信息

Uenoyama Yoshitaka, Fukuyama Takahide, Ryu Ilhyong

机构信息

Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

出版信息

Org Lett. 2007 Mar 1;9(5):935-7. doi: 10.1021/ol070080c. Epub 2007 Jan 30.

DOI:10.1021/ol070080c

PMID:17261008

Abstract

[reaction: see text] Substitution at nitrogen by alpha,beta-unsaturated acyl radicals took place accompanied by elimination of an alpha-phenethyl radical. This reaction led to the development of a new carbonylative annulation method for five- to seven-membered ring lactams.

摘要

[反应：见正文] 氮原子被α,β-不饱和酰基自由基取代的同时伴随着α-苯乙基自由基的消除。该反应促成了一种用于合成五至七元环内酰胺的新型羰基化环化方法的开发。