Stokely E M, Buja L M, Lewis S E, Parkey R W, Bonte F J, Harris R A, Willerson J T
J Nucl Med. 1976 Jan;17(1):1-5.
Myocardial scintigrams using 99mTc-stannous pyrophosphate (99mTc-PYP) can be used to measure myocardial infarcts produced in dogs by proximal ligation of the left anterior descending coronary artery. Seven dogs had 99mTc-PYP myocardial scintigraphy performed 24--32 hr after ligation of the proximal left anterior artery. In each dog the scintigrams showed increased 99mTc-PYP uptake in the distribution of the artery. The scintigraphically visible areas of infarction, measured using interactive computer-aided techniques, were compared subsequently with independent histologic measurements of myocardial infarct size. Several methods for using the area measurements to estimate infarct size were tested. The most successful method (r = 0.92, p less than 0.01) assumed a linear relationship between the largest scintigraphic infarct area and the histologically determined infarct weight. The results suggest that 99mTc-PYP myocardial scintigrams provide a useful noninvasive method for measuring infarct size in dogs with proximal ligation of the left anterior descending coronary artery.
使用99m锝焦磷酸亚锡（99mTc-PYP）进行的心肌闪烁扫描可用于测量通过结扎左冠状动脉前降支近端在犬类中产生的心肌梗死。7只犬在结扎左冠状动脉前降支近端后24至32小时进行了99mTc-PYP心肌闪烁扫描。每只犬的闪烁扫描图显示在动脉分布区域99mTc-PYP摄取增加。随后，使用交互式计算机辅助技术测量的闪烁扫描可见梗死区域与心肌梗死大小的独立组织学测量结果进行了比较。测试了几种使用面积测量来估计梗死大小的方法。最成功的方法（r = 0.92，p < 0.01）假定最大闪烁扫描梗死面积与组织学确定的梗死重量之间存在线性关系。结果表明，99mTc-PYP心肌闪烁扫描为测量左冠状动脉前降支近端结扎的犬类梗死大小提供了一种有用的非侵入性方法。
