Williams C C, Nishiyama H, Adolph R J, Romhilt D W, Sodd V J, Saenger E L, Gabel M
J Nucl Med. 1977 Sep;18(9):905-9.
Etidronate and pyrophosphate, labeled with Tc-95m and Tc-99m, were studied in experimentally infarcted mongrel dogs. A distribution study was conducted 2 hr after simultaneous administration of both agents in two groups of dogs. In one group, the injection was made 15 min after release of a 2-hr coronary arterial ligation. Another group was injected 48 hr after release of the ligation. The uptakes for each radiopharmaceutical and the ratio of uptakes for each sample were computed. The data show pyrophosphate to be a superior agent for the imaging of acute myocardial infarcts because of the higher uptake by infarcted myocardium and the greater contrast between infarcted myocardium and neighboring organs.
用锝-95m和锝-99m标记的依替膦酸盐和焦磷酸盐在实验性梗死的杂种狗身上进行了研究。在两组狗同时给予两种药物后2小时进行了分布研究。在一组中，在冠状动脉结扎2小时后松开15分钟进行注射。另一组在结扎松开48小时后注射。计算每种放射性药物的摄取量以及每个样本的摄取量比值。数据表明，焦磷酸盐是急性心肌梗死成像的更佳药物，因为梗死心肌摄取量更高，且梗死心肌与邻近器官之间的对比度更大。
