中枢性NK-3速激肽受体激动剂森克肽对胃分泌的抑制作用。

Inhibitory role on gastric secretion of a central NK-3 tachykinin receptor agonist, senktide.

作者信息

Improta G, Broccardo M

机构信息

Institute of Pharmacology III, University La Sapienza, Rome, Italy.

出版信息

Peptides. 1991 Nov-Dec;12(6):1433-4. doi: 10.1016/0196-9781(91)90228-h.

DOI:10.1016/0196-9781(91)90228-h

PMID:1726124

Abstract

When administered intracerebroventricularly, the highly selective NK-3 tachykinin receptor agonist senktide possesses a potent and dose-related inhibitory effect on gastric acid secretion. The central mechanism governing the antisecretory effect of senktide was examined in perfused-stomach rats by studying its influence on gastric acid secretion elicited by the secretagogues histamine, pentagastrin and bethanechol. Given intracerebroventricularly, senktide reduced the acid response to histamine, but not that to pentagastrin or bethanechol. Stimulation of NK-3 receptors in rat brain thus appears to inhibit gastric acid secretion through histaminergic pathways.

摘要

当通过脑室内给药时，高选择性的NK-3速激肽受体激动剂senktide对胃酸分泌具有强效且剂量相关的抑制作用。通过研究其对组胺、五肽胃泌素和氨甲酰甲胆碱等促分泌剂引起的胃酸分泌的影响，在灌流胃大鼠中研究了senktide抗分泌作用的中枢机制。脑室内给予senktide可降低对组胺的酸反应，但对五肽胃泌素或氨甲酰甲胆碱引起的酸反应无影响。因此，刺激大鼠脑中的NK-3受体似乎通过组胺能途径抑制胃酸分泌。