慢性吗啡处理大鼠对胆碱能和组胺能刺激的胃酸分泌反应。

Gastric acid secretory responses to cholinergic and histaminergic stimulation in chronic morphine-treated rats.

作者信息

Ho M M, Dai S, Ogle C W

出版信息

Neuropharmacology. 1986 Aug;25(8):935-8. doi: 10.1016/0028-3908(86)90024-9.

Abstract

The effects of chronic morphine administration on cholinergic and histaminergic activities were evaluated in rats by observing their gastric acid secretory responses to secretagogues. The responses of in-vivo perfused stomachs to 2-deoxy-D-glucose or pentagastrin, and of the isolated gastric mucosa to histamine or bethanechol, were not significantly different between naive and chronic morphine-treated animals. It is suggested that the chronic morphine-treated rats exhibit normal cholinergic and histaminergic activities as well as receptor sensitivities to acetylcholine and histamine.

摘要

通过观察大鼠对促分泌剂的胃酸分泌反应，评估长期给予吗啡对胆碱能和组胺能活性的影响。在未处理的大鼠和长期给予吗啡的大鼠之间，体内灌注胃对2-脱氧-D-葡萄糖或五肽胃泌素的反应，以及分离的胃黏膜对组胺或氨甲酰甲胆碱的反应，均无显著差异。这表明，长期给予吗啡的大鼠表现出正常的胆碱能和组胺能活性，以及对乙酰胆碱和组胺的受体敏感性。