Dennison Cheryl R, Post Wendy S, Kim Miyong T, Bone Lee R, Cohen David, Blumenthal Roger S, Rame J Eduardo, Roary Mary C, Levine David M, Hill Martha N
School of Nursing, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Am J Hypertens. 2007 Feb;20(2):164-71. doi: 10.1016/j.amjhyper.2006.08.003.
African American men with hypertension (HTN) in low socioeconomic urban environments continue to achieve poor rates of HTN control.
In a 5-year randomized clinical trial with 309 hypertensive urban African American men aged 21 to 54 years, the effectiveness of a more intensive educational/behavioral/pharmacologic intervention provided by a nurse practitioner/community health worker/physician team was compared to less intensive information and referral intervention. Changes in behavioral factors, health care utilization, blood pressure (BP) control, left ventricular hypertrophy (LVH), and renal insufficiency were evaluated.
Follow-up rates exceeded 89% of available men. The ranges of mean annual systolic BP/diastolic BP change from the baseline to each year follow-up were -3.7 to -10.1/-4.9 to -12.3 mm Hg for the more intensive group and +3.4 to -3.0/-1.8 to -8.7 mm Hg for the less intensive group. The annual proportion of men with controlled BP (<140/90 mm Hg) ranged from 17% to 44% in the more intensive group and 21% to 36% in the less intensive group. At 5 years the more intensive group had less LVH than the less intensive group and 17% of the men were deceased primarily due to narcotic or alcohol intoxication (36%) and cardiovascular causes (19%).
An appropriate educational/behavioral intervention significantly improved BP control and reduced some sequelae of HTN in a young African American male population. Improvement in risk factors other than HTN was limited and sustained control of HTN was difficult to maintain during 5 years.
生活在社会经济水平较低的城市环境中的非裔美国高血压男性患者,其高血压控制率仍然很低。
在一项为期5年的随机临床试验中,对309名年龄在21至54岁之间的城市非裔美国高血压男性患者进行研究,比较了由执业护士/社区卫生工作者/医生团队提供的强化教育/行为/药物干预与非强化信息及转诊干预的效果。评估了行为因素、医疗保健利用情况、血压(BP)控制、左心室肥厚(LVH)和肾功能不全的变化。
随访率超过了89%的可用男性患者。强化组从基线到每年随访时平均收缩压/舒张压的年变化范围为-3.7至-10.1/-4.9至-12.3 mmHg,非强化组为+3.4至-3.0/-1.8至-8.7 mmHg。强化组血压得到控制(<140/90 mmHg)的男性患者的年比例在17%至44%之间,非强化组在21%至36%之间。5年后,强化组的左心室肥厚情况比非强化组轻,17%的男性患者死亡,主要原因是麻醉品或酒精中毒(36%)和心血管疾病(19%)。
适当的教育/行为干预显著改善了年轻非裔美国男性人群的血压控制,并减少了高血压的一些后遗症。除高血压外,危险因素的改善有限,且在5年期间难以维持高血压的持续控制。