Cheour Elhem, Ajlani Houda, Ben Abdelghni Kawther, Sahli Hela, Farah Afef, Hamza Sami, Fendri Leila, Sellami Slaheddine
Service de Rhumatologie, Hôpital la Rabta, Tunis, Tunisie.
Tunis Med. 2006 Sep;84(9):527-31.
Gout is one of the oldest and better understood among rheumatic diseases. It is characterized by chronic hyperuricemia and recurrent attacks of acute arthritis provoked by release of sodium urate crystals into joints. The manifestations of Gout can be abolished by lifelong urate-lowering therapy maintainine serum urate levels under 360 mmol/l. The management of a minority of patients, including those with renal impairment, is difficult and often unsatisfactory because of restricted treatment options. In this paper; the current options for treating hyperuricemia are first discussed then followed by new approches.
痛风是最古老且人们了解较多的风湿性疾病之一。其特征为慢性高尿酸血症以及尿酸钠结晶释放至关节引发的急性关节炎反复发作。通过终身降尿酸治疗将血清尿酸水平维持在360 mmol/l以下,痛风的症状可得以消除。由于治疗选择受限,少数患者(包括肾功能受损患者)的治疗较为困难且往往不尽人意。本文首先讨论治疗高尿酸血症的现有选择,然后介绍新的方法。