Pietruszewska Wioletta, Kobos Józef, Bojanowska-Poźniak Katarzyna, Durko Marcin, Gryczyński Maciej
Katedra Otolaryngologii, Klinika Laryngologii i Onkologii Laryngologicznej UM w Lodzi.
Otolaryngol Pol. 2006;60(5):697-702.
Fibronectin is one of the extracellular matrix glycoprotein, that plays an important role in cancer invasion and progression. Our purpose was to evaluate fibronectin expression and its possible prognostic value in laryngeal cancer. Forty-one patients (six female and thirty-five male) surgically treated for laryngeal cancer were included in the study. The expression and distribution of fibronectin was immunohistochemically determined by using monoclonal antibody against fibronectin. Low expression of fibronectin was detected around the individual carcinoma cells, but large amounts were present in the invasive tumour front and the cancer surrounding stroma was strongest positive for fibronectin. By univariate analysis the level of fibronectin expression on the border of the invasive tumour front was proved to be correlated with tumor stage (p = 0.03). There was a significant association between the defect of ECM and overall survival (p > 0.05). These observation indicates that testing the distribution and the expression of ECM seems to be useful to evaluate the histological grading of malignancy of laryngeal cancer and to be helpful to prognosticate the overall survival while measured on the border of tumour proliferative front in laryngeal patients. The results demonstrate that fibronectin amount may be useful in evaluating the invasion potential of the tumour.
纤连蛋白是一种细胞外基质糖蛋白，在癌症侵袭和进展中起重要作用。我们的目的是评估纤连蛋白在喉癌中的表达及其可能的预后价值。本研究纳入了41例接受喉癌手术治疗的患者（6例女性，35例男性）。使用抗纤连蛋白单克隆抗体通过免疫组织化学方法确定纤连蛋白的表达和分布。在单个癌细胞周围检测到纤连蛋白低表达，但在侵袭性肿瘤前沿存在大量纤连蛋白，且癌周基质的纤连蛋白阳性最强。单因素分析表明，侵袭性肿瘤前沿边界处的纤连蛋白表达水平与肿瘤分期相关（p = 0.03）。细胞外基质缺陷与总生存期之间存在显著关联（p > 0.05）。这些观察结果表明，检测细胞外基质的分布和表达似乎有助于评估喉癌的恶性组织学分级，并有助于预测喉癌患者在肿瘤增殖前沿边界处测量的总生存期。结果表明，纤连蛋白的含量可能有助于评估肿瘤的侵袭潜能。
