Izmir Training and Research Hospital, Department of Pathology, Yesilyurt, Turkey.
Pathol Res Pract. 2011 Oct 15;207(10):628-33. doi: 10.1016/j.prp.2011.07.010. Epub 2011 Sep 21.
ETS-1 protein is one of the key regulators in tumor invasion and progression. We aimed to evaluate the role of ETS-1 in the invasiveness and progression of laryngeal squamous carcinoma, as well as to determine the correlations between clinicopathological characteristics and expression of this molecule. We assessed the levels of ETS-1 in a total of 96 laryngeal specimens of varying degrees of dysplasia, microinvasive squamous carcinoma (8), and invasive squamous carcinoma (60), using normal mucosal epithelium (10) as a positive control. The relationship between ETS-1 expression and clinicopathological parameters of laryngeal carcinoma was also analyzed. We found a significantly higher ETS-1 expression in invasive laryngeal squamous cell carcinomas than in dysplasia (P<0.001). A correlation between ETS-1 expression scores and grade was detected - T factor, stage, cartilage invasion, lymph node metastasis, as well as depth of invasion in laryngeal tumors. Our study is the first to demonstrate that ETS-1 expression is significantly increased in invasive carcinoma, but it is absent in low-moderate grade laryngeal dysplasia and non-neoplastic laryngeal mucosa. This data suggest that ETS-1 expression may play an important role in tumor invasion, and may function in the initiation of the invasive process in laryngeal squamous cell carcinoma.
ETS-1 蛋白是肿瘤侵袭和进展的关键调节因子之一。我们旨在评估 ETS-1 在喉鳞状细胞癌侵袭和进展中的作用，并确定该分子的表达与临床病理特征之间的相关性。我们使用正常黏膜上皮（10 例）作为阳性对照，评估了总共 96 例不同程度异型增生、微侵袭性鳞状细胞癌（8 例）和侵袭性鳞状细胞癌（60 例）中 ETS-1 的水平。还分析了 ETS-1 表达与喉癌临床病理参数之间的关系。我们发现侵袭性喉鳞状细胞癌中 ETS-1 的表达明显高于异型增生（P<0.001）。检测到 ETS-1 表达评分与 T 因子、分期、软骨侵犯、淋巴结转移以及喉肿瘤的浸润深度之间存在相关性。我们的研究首次表明，在侵袭性癌中 ETS-1 的表达显著增加，但在低-中等级别喉异型增生和非肿瘤性喉黏膜中不存在。这些数据表明 ETS-1 表达可能在肿瘤侵袭中发挥重要作用，并可能在喉鳞状细胞癌的侵袭过程起始中发挥作用。
