[间质性疾病患者支气管肺泡灌洗术中弹性蛋白酶和α2-巨球蛋白的测定及其临床意义]
[Determination of elastase and alpha 2-macroglobulin in bronchoalveolar lavage fluid in patients with interstitial diseases and its clinical significance].
作者信息
Li Z H
机构信息
Institute of Respiratory Disease, China Medical University.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 1991 Dec;14(6):333-5, 375-6.
Determination of elastase and its inhibitor alpha 2-Macroglobulin was done in BALF in 40 patients with ILD (study group) and 10 healthy volunteers (control group). The results showed that BALF levels of elastase and alpha 2-macroglobulin in study group were significantly higher than those in control group (P less than 0.01; P less than 0.05). Correlation was found between BALF elastase levels and cell count (r = 0.3214, P less than 0.05). It was suggested that elastase may play a role in the development of pulmonary fibrosis in interstitial lung diseases.
对40例间质性肺病（ILD）患者（研究组）和10名健康志愿者（对照组）的支气管肺泡灌洗液（BALF）进行了弹性蛋白酶及其抑制剂α2-巨球蛋白的测定。结果显示，研究组BALF中弹性蛋白酶和α2-巨球蛋白水平显著高于对照组（P<0.01；P<0.05）。发现BALF弹性蛋白酶水平与细胞计数之间存在相关性（r = 0.3214，P<0.05）。提示弹性蛋白酶可能在间质性肺病肺纤维化的发生发展中起作用。
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