[特发性间质性肺炎患者血清及支气管肺泡灌洗液中内皮素-1活性变化及其临床意义]

[Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance].

作者信息

Li Z, Xia S, Hou X

机构信息

Institute of the Respiratory Disease, China Medical University, Shenyang 110001.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jul;22(7):411-3.

PMID:11775813

Abstract

OBJECTIVE

To evaluate the roles of the Endothelin-1 (ET-1) in pathogenesis of the patients with interstitial lung disease (ILD).

METHODS

The ET-1 activities in the serum and BALF from 10 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects non-smokers were determined using the radio-immunoassay.

RESULTS

In the activities of ET-1 in the serum and BALF in the patients with sarcoiosis (62 +/- 29 and 17.0 +/- 2.4) ng/L and in the IPF (77 +/- 71 and 10 +/- 3) ng/L. was higher than those in the normal control subjects (20 +/- 8 and 4.0 +/- 0.6) ng/L. The activities of ET-1 in serum was negative correlated with PaO2 (r = -0.538, P < 0.01). The level of ET-1 in the BALF of the patient was positive correlated with total cells in BALF (r = 0.649, P < 0.01). The levels of ET-1 in the BALF in the sarcoidosis was positive correlated with the percentage of lymphocyte (r = 0.712, P < 0.01) but in patients with IPF was positive correlated with the percentage of neutrophil (r = 0.813, P < 0.01).

CONCLUSIONS

ET-1 might play an important role in pathogenic of the patients with sarcoidosis and IPF. The levels of ET-1 can act as the markers of activity of disease.

摘要

目的

评估内皮素-1（ET-1）在间质性肺疾病（ILD）患者发病机制中的作用。

方法

采用放射免疫分析法测定10例结节病患者、7例特发性肺纤维化（IPF）患者及8名非吸烟正常对照者血清和支气管肺泡灌洗液（BALF）中的ET-1活性。

结果

结节病患者血清和BALF中ET-1活性分别为（62±29）和（17.0±2.4）ng/L，IPF患者分别为（77±71）和（10±3）ng/L，均高于正常对照者（20±8）和（4.0±0.6）ng/L。血清ET-1活性与动脉血氧分压（PaO2）呈负相关（r = -0.538，P < 0.01）。患者BALF中ET-1水平与BALF中总细胞数呈正相关（r = 0.649，P < 0.01）。结节病患者BALF中ET-1水平与淋巴细胞百分比呈正相关（r = 0.712，P < 0.01），而IPF患者与中性粒细胞百分比呈正相关（r = 0.813，P < 0.01）。