Zeng Weifen F, Navaratne Kapila, Prayson Richard A, Weil Robert J
The Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
J Clin Pathol. 2007 Feb;60(2):218-21. doi: 10.1136/jcp.2006.036806.
Chromosomal abnormalities and genomic instability are common features of, and possible driving forces in, tumorigenesis. Recently, several mitotic proteins that are critical to proper chromosome segregation have been identified. Members of the Aurora kinase family have been identified as having important roles in mitosis; overexpression induces multicellularity and fosters polyploidy. As aneuploidy is a common feature of malignant gliomas, particularly glioblastomas (GBMs), we examined 25 prospectively collected GBMs to assess the role that overexpression of one member of this family, Aurora B, might have in the clinical behaviour of GBMs. Aurora B expression levels were markedly correlated with a shortened survival. Aurora B expression was not directly related to age, tumour proliferation status or to several common molecular changes found in GBMs. These results suggest that Aurora B may be a prognostic feature of impaired survival and a novel therapeutic target in some patients.
染色体异常和基因组不稳定是肿瘤发生的常见特征及可能的驱动因素。最近，已鉴定出几种对正确染色体分离至关重要的有丝分裂蛋白。极光激酶家族成员已被确定在有丝分裂中发挥重要作用；过表达会诱导多细胞性并促进多倍体形成。由于非整倍体是恶性胶质瘤尤其是胶质母细胞瘤（GBM）的常见特征，我们检测了25例前瞻性收集的GBM，以评估该家族一个成员极光B的过表达可能在GBM临床行为中所起的作用。极光B的表达水平与生存期缩短显著相关。极光B的表达与年龄、肿瘤增殖状态或GBM中发现的几种常见分子变化无直接关系。这些结果表明，极光B可能是生存受损的一个预后特征，并且是部分患者的一个新治疗靶点。
