Kelly Michael E, Schültke Elisabeth, Fiedler Stephan, Nemoz Christian, Guzman Raphael, Corde Stephanie, Esteve Francois, LeDuc Geraldine, Juurlink Bernhard H J, Meguro Kotoo
Division of Neurosurgery, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada.
Phys Med Biol. 2007 Feb 21;52(4):1001-12. doi: 10.1088/0031-9155/52/4/009. Epub 2007 Jan 23.
K-edge digital subtraction angiography (KEDSA), a recently developed synchrotron-based technique, utilizes monochromatic radiation and allows acquisition of high-quality angiography images after intravenous administration of contrast agent. We tested KEDSA for its suitability for intravenous cerebral angiography in an animal model. Adult male New Zealand rabbits were subjected to either angiography with conventional x-ray equipment or synchrotron-based intravenous KEDSA, using an iodine-based contrast agent. Angiography with conventional x-ray equipment after intra-arterial administration of contrast agent demonstrated the major intracranial vessels but no smaller branches. KEDSA was able to visualize the major intracranial vessels as well as smaller branches in both radiography mode (planar images) and tomography mode. Visualization was achieved with as little as 0.5 ml kg-1 of iodinated contrast material. We were able to obtain excellent visualization of the cerebral vasculature in an animal model using intravenous injection of contrast material, using synchrotron-based KEDSA.
K 边数字减影血管造影术（KEDSA）是一种最近开发的基于同步加速器的技术，它利用单色辐射，并允许在静脉注射造影剂后采集高质量的血管造影图像。我们在动物模型中测试了 KEDSA 用于静脉脑造影的适用性。成年雄性新西兰兔接受了使用碘基造影剂的传统 X 射线设备血管造影或基于同步加速器的静脉 KEDSA。动脉内注射造影剂后使用传统 X 射线设备进行血管造影可显示主要颅内血管，但无法显示较小分支。KEDSA 能够在射线照相模式（平面图像）和断层扫描模式下显示主要颅内血管以及较小分支。使用低至 0.5 ml kg-1 的碘化造影剂即可实现可视化。我们能够通过基于同步加速器的 KEDSA 静脉注射造影剂，在动物模型中获得脑血管系统的出色可视化效果。
