Jeng Fuh-Cherng, Abbas Paul J, Brown Carolyn J, Miller Charles A, Nourski Kirill V, Robinson Barbara K
Department of Speech Pathology and Audiology, Department of Otolaryngology--HNS, University of Iowa, Iowa City, Iowa, USA.
Audiol Neurootol. 2007;12(2):101-12. doi: 10.1159/000097796. Epub 2006 Dec 6.
Most cochlear implant systems available today provide the user with information about the envelope of the speech signal. The goal of this study was to explore the feasibility of recording electrically evoked auditory steady-state response (ESSR) and in particular to evaluate the degree to which the response recorded using electrical stimulation could be separated from stimulus artifact. Sinusoidally amplitude-modulated electrical stimuli with alternating polarities were used to elicit the response in adult guinea pigs. Separation of the stimulus artifact from evoked neural responses was achieved by summing alternating polarity responses or by using spectral analysis techniques. The recorded response exhibited physiological response properties including a pattern of nonlinear growth and their abolishment following euthanasia or administration of tetrodotoxin. These findings demonstrate that the ESSR is a response generated by the auditory system and can be separated from electrical stimulus artifact. As it is evoked by a stimulus that shares important features of cochlear implant stimulation, this evoked potential may be useful in either clinical or basic research efforts.
如今大多数可用的人工耳蜗系统为用户提供语音信号包络的信息。本研究的目的是探讨记录电诱发听觉稳态反应（ESSR）的可行性，尤其是评估使用电刺激记录的反应与刺激伪迹分离的程度。使用具有交替极性的正弦幅度调制电刺激在成年豚鼠中诱发反应。通过对交替极性反应求和或使用频谱分析技术实现刺激伪迹与诱发神经反应的分离。记录的反应表现出包括非线性增长模式以及在安乐死或给予河豚毒素后反应消失在内的生理反应特性。这些发现表明，ESSR是由听觉系统产生的反应，并且可以与电刺激伪迹分离。由于它是由具有人工耳蜗刺激重要特征的刺激诱发的，这种诱发电位可能在临床或基础研究工作中有用。
