Pushkareva M, Obeid L M, Hannun Y A
Liposome Co., Princeton, NJ 08540-6619, USA.
Immunol Today. 1995 Jun;16(6):294-7. doi: 10.1016/0167-5699(95)80184-7.
The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentiation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of action of this stress-activated pathway.
几种细胞因子的作用是通过激活信号转导的鞘磷脂循环来介导的。该途径的产物神经酰胺正成为一种细胞内信使，介导对终末分化、细胞凋亡和细胞周期停滞的影响。在此，玛丽娜·普什卡列娃、莉娜·奥贝德和优素福·汉农讨论了这条应激激活途径的调控及其作用机制。
