Aksenova N N, Ivanov V A, Kovaleva Z V, Pleskach V A, Firulina I I, Fel' V Ia
Tsitologiia. 1991;33(8):90-5.
Monoclonal antibodies to the HNK-1 differentiated antigen of natural killer cells have been obtained. A glycoprotein of the white human brain connected with myelin was used as an antigen for immunization of mice. The monoclonal antibodies obtained are shown to reduce the cytotoxic activity of a human blood mononuclear fraction as much as by 65% in relation to the human lymphoblastoma cell culture K-562. Their interaction with the surface antigen of mononuclears was shown by immunofluorescent method. Monoclonal antibodies belong to the class of immunoglobulins M.
已获得针对自然杀伤细胞HNK-1分化抗原的单克隆抗体。用人脑白质中与髓磷脂相关的一种糖蛋白作为抗原免疫小鼠。所获得的单克隆抗体显示，相对于人淋巴母细胞瘤细胞培养物K-562，可使人类血液单核细胞组分的细胞毒性活性降低多达65%。通过免疫荧光法显示了它们与单核细胞表面抗原的相互作用。单克隆抗体属于免疫球蛋白M类。
