肥胖症和代谢综合征未来管理中的脂肪因子及脂肪细胞靶点
Adipokines and adipocyte targets in the future management of obesity and the metabolic syndrome.
作者信息
Kralisch S, Bluher M, Paschke R, Stumvoll M, Fasshauer M
机构信息
Department of Internal Medicine, University of Leipzig, Leipzig, Germany.
出版信息
Mini Rev Med Chem. 2007 Jan;7(1):39-45. doi: 10.2174/138955707779317821.
PMID:17266636
Abstract
The role of adipocytes has been recently better understood. Several adipocytokines have been identified, including leptin, a main regulator of appetite and energy expenditure, adiponectin and others, as novel insulin-sensitizers/insulin-mimetics, and some others inducing insulin resistance. Adipocytokines thus represent interesting novel drug targets in the future management of obesity.
摘要
脂肪细胞的作用最近得到了更好的理解。已鉴定出几种脂肪细胞因子，包括瘦素（一种食欲和能量消耗的主要调节因子）、脂联素等，作为新型胰岛素增敏剂/胰岛素模拟物，还有一些会诱导胰岛素抵抗。因此，脂肪细胞因子在未来肥胖症的治疗中代表了有趣的新型药物靶点。
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