Skrzydlewska E, Chyczewski L, Worowski K
Zakładu Analizy Instrumentalnej, Akademii Medycznej, Białymstoku.
Rocz Akad Med Bialymst (1989). 1990;35-36:163-75.
Increased activity of cathepsin A and D in the cytosol fraction and homogenate of the liver of rats intoxicated for 4 weeks with ethanol (0.6 g/100 g of the body weight) was found. The cytosol cathepsin A and D activities were unaffected under the influence of Levamisole and isoprinosine++. Encorton reduced the activity of both cathepsins in the cytosol fraction while it did not diminish their activities in the liver homogenates. Encorton, and to a markedly lesser degree, Levamisole and isoprinosine++ caused a regression of vacuolar degeneration and of necrotic lesions and an increase in the number of glycogen granules in the livers of ethanol-intoxicated rats.
发现用乙醇（0.6克/100克体重）对大鼠进行4周中毒处理后，其肝脏细胞溶质部分和匀浆中组织蛋白酶A和D的活性增加。左旋咪唑和异丙肌苷++对细胞溶质组织蛋白酶A和D的活性没有影响。恩考酮降低了细胞溶质部分中两种组织蛋白酶的活性，但对肝脏匀浆中它们的活性没有降低作用。恩考酮以及程度明显较轻的左旋咪唑和异丙肌苷++导致乙醇中毒大鼠肝脏中的空泡变性和坏死性病变消退，糖原颗粒数量增加。
