儿童B前体急性淋巴细胞白血病中中期因子基因表达增加。
Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia.
作者信息
Hidaka Hirokazu, Yagasaki Hiroshi, Takahashi Yoshiyuki, Hama Asahito, Nishio Nobuhiro, Tanaka Makito, Yoshida Nao, Villalobos Itzel Bustos, Wang Yue, Xu Yinyan, Horibe Keizo, Chen Sen, Kadomatsu Kenji, Kojima Seiji
机构信息
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
出版信息
Leuk Res. 2007 Aug;31(8):1045-51. doi: 10.1016/j.leukres.2006.12.008. Epub 2007 Jan 30.
Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.
中期因子（MK）是一种肝素结合生长因子，在多种实体癌中过度表达。然而，其在急性白血病中的表达情况尚未明确。我们采用实时定量聚合酶链反应（PCR）检测了94例急性白血病患儿的MK基因表达。在41例B系前体急性淋巴细胞白血病（ALL）患者中，有30例的MK基因表达高于正常骨髓。MK基因在超过半数的FAB M1和M2型急性髓系白血病（AML）患者中也呈过度表达。通过实时定量PCR对MK基因进行定量分析，有望成为B系前体ALL患儿的预后标志物及微小残留病标志物。
Zotero 插件