PRAME表达在儿童急性白血病诊断中的定量评估
Quantitative assessment of PRAME expression in diagnosis of childhood acute leukemia.
作者信息
Spanaki A, Perdikogianni C, Linardakis E, Kalmanti M
机构信息
Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, University of Crete Medical School, 71110 Heraklion, Crete, Greece.
出版信息
Leuk Res. 2007 May;31(5):639-42. doi: 10.1016/j.leukres.2006.06.006. Epub 2006 Jul 24.
PRAME is expressed at low levels in normal testes and highly in solid tumor cells and hematological malignancies. The purpose of this study was to investigate PRAME expression levels in children with acute leukemia with real-time PCR analysis. Seventeen children with newly diagnosed or relapsed acute leukemia (11 ALL, 4 AML, 1 acute myeloblastic leukemia secondary to MDS, 1 ALL at relapse) and a control group of seven children were studied. Overexpression of PRAME was found in 52.9% (3 AML, 6 ALL) of the patients studied. No important correlation between PRAME expression and the patients' prognosis was observed. The above findings indicate that PRAME expression in acute leukemia does not seem to be of prognostic significance, whereas it might represent a candidate marker for the monitoring of minimal residual disease.
PRAME在正常睾丸中低表达，而在实体瘤细胞和血液系统恶性肿瘤中高表达。本研究旨在通过实时PCR分析调查急性白血病患儿中PRAME的表达水平。研究了17例新诊断或复发的急性白血病患儿（11例急性淋巴细胞白血病、4例急性髓系白血病、1例继发于骨髓增生异常综合征的急性髓细胞白血病、1例复发的急性淋巴细胞白血病）以及7例儿童组成的对照组。在所研究的患者中，52.9%（3例急性髓系白血病、6例急性淋巴细胞白血病）发现PRAME过表达。未观察到PRAME表达与患者预后之间的重要相关性。上述发现表明，PRAME在急性白血病中的表达似乎没有预后意义，而它可能代表一个用于监测微小残留病的候选标志物。
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