新型丙型肝炎病毒自然基因间型（2/5）重组体
New natural intergenotypic (2/5) recombinant of hepatitis C virus.
作者信息
Legrand-Abravanel Florence, Claudinon Julie, Nicot Florence, Dubois Martine, Chapuy-Regaud Sabine, Sandres-Saune Karine, Pasquier Christophe, Izopet Jacques
机构信息
Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563, IFR30, 330 Ave. de Grande-Bretagne, TSA 40031, 31059 Toulouse Cédex 9, France.
出版信息
J Virol. 2007 Apr;81(8):4357-62. doi: 10.1128/JVI.02639-06. Epub 2007 Jan 31.
Abstract
A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.
摘要
将在法国西南部发现的一株丙型肝炎病毒（HCV）的9.2 kb序列与HCV序列数据库中的参考毒株序列进行了比较。我们发现了一种重组病毒，其5'端为2型基因型，3'端为5型基因型。交叉点位于NS2和NS3基因之间。在HCV流行病学和进化研究以及病毒对抗病毒治疗反应的预测中，现在必须考虑HCV基因型之间的重组。了解重组点的位置对于构建感染性嵌合病毒也可能有用。
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