30多岁男性的早期风险因素、工作压力与动脉粥样硬化：芬兰青年人心血管风险研究
Early risk factors, job strain, and atherosclerosis among men in their 30s: the Cardiovascular Risk in Young Finns Study.
作者信息
Kivimäki Mika, Hintsanen Mirka, Keltikangas-Järvinen Liisa, Elovainio Marko, Pulkki-Råback Laura, Vahtera Jussi, Viikari Jorma S A, Raitakari Olli T
机构信息
Department of Epidemiology and Public Health, University College London, London, England.
出版信息
Am J Public Health. 2007 Mar;97(3):450-2. doi: 10.2105/AJPH.2005.078873. Epub 2007 Jan 31.
Abstract
We examined whether preemployment influences confounded the association between job strain and atherosclerosis. We assessed biological, familial, and socioeconomic risk factors of coronary heart disease at 12 to 18 years of age and job strain and carotid artery intima-media thickness at 33 to 39 years of age for a cohort of 358 men. Adolescent risk factors predicted adult intima-media thickness but had little effect on the dose-response relation between greater job strain and greater intima-media thickness. Pre-employment influences did not confound the association between job strain and atherosclerosis.
摘要
我们研究了入职前的影响因素是否混淆了工作压力与动脉粥样硬化之间的关联。我们评估了358名男性队列在12至18岁时冠心病的生物学、家族和社会经济风险因素，以及在33至39岁时的工作压力和颈动脉内膜中层厚度。青少年风险因素可预测成人的内膜中层厚度，但对更大的工作压力与更大的内膜中层厚度之间的剂量反应关系影响甚微。入职前的影响因素并未混淆工作压力与动脉粥样硬化之间的关联。
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