伴有和不伴有认知行为疗法的惊恐障碍患者药物副作用报告的比较。
A comparison of medication side effect reports by panic disorder patients with and without concomitant cognitive behavior therapy.
作者信息
Marcus Sue M, Gorman Jack, Shear M Katherine, Lewin David, Martinez Jose, Ray Susan, Goetz Raymond, Mosovich Serge, Gorman Lauren, Barlow David, Woods Scott
机构信息
Mount Sinai School of Medicine, Department of Psychiatry, Division of Biostatistics, Box 1230, One Gustave L. Levy Place, New York, NY 10029-6574.
出版信息
Am J Psychiatry. 2007 Feb;164(2):273-5. doi: 10.1176/ajp.2007.164.2.273.
OBJECTIVE
The authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects.
METHOD
Data were analyzed for 172 panic disorder patients who were randomly assigned to receive imipramine alone, imipramine plus CBT, or placebo. Mixed-effects models were used to assess longitudinal differences among the treatment groups with respect to side effect burden and dropout rates during the acute, maintenance, and follow-up phases of treatment.
RESULTS
Patients treated with imipramine plus CBT experienced less severe fatigue/weakness, dry mouth, and sweating and had a lower rate of dropout due to side effects compared with those treated with imipramine only.
CONCLUSIONS
The addition of CBT to medication treatment with imipramine was associated with less severe side effects and fewer dropouts due to perceived side effects than treatment with imipramine alone.
目的
作者评估了对于惊恐障碍患者，在丙咪嗪治疗基础上加用认知行为疗法（CBT）是否能降低副作用的严重程度以及因副作用导致的脱落率。
方法
对172例惊恐障碍患者的数据进行分析，这些患者被随机分配接受单独丙咪嗪治疗、丙咪嗪加CBT治疗或安慰剂治疗。采用混合效应模型评估治疗组在治疗的急性期、维持期和随访期副作用负担和脱落率方面的纵向差异。
结果
与仅接受丙咪嗪治疗的患者相比，接受丙咪嗪加CBT治疗的患者出现的疲劳/虚弱、口干和出汗症状较轻，且因副作用导致的脱落率较低。
结论
与单独使用丙咪嗪治疗相比，在丙咪嗪药物治疗基础上加用CBT与更轻的副作用以及更少因感觉有副作用而导致的脱落情况相关。
Zotero 插件