Hofmann Stefan G, Meuret Alicia E, Rosenfield David, Suvak Michael K, Barlow David H, Gorman Jack M, Shear M Katherine, Woods Scott W
Department of Psychology, Boston University, Boston, MA 02215, USA.
J Consult Clin Psychol. 2007 Jun;75(3):374-9. doi: 10.1037/0022-006X.75.3.374.
Cognitive-behavioral therapy (CBT) and pharmacotherapy are similarly effective for treating panic disorder with mild or no agoraphobia, but little is known about the mechanism through which these treatments work. The present study examined some of the criteria for cognitive mediation of treatment change in CBT alone, imipramine alone, CBT plus imipramine, and CBT plus placebo. Ninety-one individuals who received 1 of these interventions were assessed before and after acute treatment, and after a 6-month maintenance period. Multilevel moderated mediation analyses provided preliminary support for the notion that changes in panic-related cognitions mediate changes in panic severity only in treatments that include CBT.
认知行为疗法(CBT)和药物疗法在治疗伴有轻度或无广场恐惧症的惊恐障碍方面同样有效,但对于这些治疗起作用的机制却知之甚少。本研究考察了单独使用CBT、单独使用丙咪嗪、CBT加丙咪嗪以及CBT加安慰剂治疗中,治疗变化的认知中介的一些标准。对接受这些干预措施之一的91名个体在急性治疗前后以及6个月的维持期后进行了评估。多层次调节中介分析为以下观点提供了初步支持:与惊恐相关的认知变化仅在包括CBT的治疗中才介导惊恐严重程度的变化。