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Hyperthermic tumour-cell devitalization in vivo.

作者信息

Overgaard K, Overgaard J

出版信息

Acta Radiol Ther Phys Biol. 1977 May;16(1):1-16. doi: 10.3109/02841867709133928.

DOI:10.3109/02841867709133928
PMID:17268
Abstract

A review of the morphologic, biochemical and clinical effects of hyperthermia on malignant cells indicates the presence of two principally different heat-induced alterations. (1) A 'destructive' lysosomal dependent cytoplasmic reaction dominates the tumour-cell devitalization in vivo, probably influenced by the characteristic tumour cell environment. (2) 'Repressive' nuclear abnormalities may be observed, but seem to be secondary in the in vivo reaction. However, under certain conditions (combined treatment modalities) this nuclear effect may be of importance.

摘要

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