缬草提取物制剂（BIM）对大鼠睡眠-觉醒周期的影响。
Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats.
作者信息
Tokunaga Shin, Takeda Yasuhiro, Niimoto Tsuyoshi, Nishida Norihisa, Kubo Toshihiro, Ohno Tohru, Matsuura Youichi, Kawahara Yuzo, Shinomiya Kazuaki, Kamei Chiaki
机构信息
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
出版信息
Biol Pharm Bull. 2007 Feb;30(2):363-6. doi: 10.1248/bpb.30.363.
In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (gamma-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
在本研究中，我们使用睡眠障碍模型大鼠，研究了含有缬草提取物、红景天提取物和L-茶氨酸（γ-谷氨酰乙酰胺）的缬草提取物制剂（BIM）对睡眠-觉醒周期的影响，并与缬草提取物进行了比较。缬草提取物和剂量为1000 mg/kg的BIM均观察到睡眠潜伏期显著缩短。另一方面，缬草提取物和BIM对总觉醒时间、非快速眼动（非REM）睡眠和REM睡眠均无显著影响。剂量为1000 mg/kg的缬草提取物和BIM对δ波活动也无显著影响。总之，很明显BIM可作为一种具有诱导睡眠作用且不会引起睡眠-觉醒周期改变的草药。
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