吲哚里西啶和喹诺里西啶生物碱。

Indolizidine and quinolizidine alkaloids.

作者信息

Michael Joseph P

机构信息

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Wits 2050, South Africa.

出版信息

Nat Prod Rep. 2007 Feb;24(1):191-222. doi: 10.1039/b509525p. Epub 2007 Jan 3.

DOI:10.1039/b509525p

PMID:17268613

Abstract

This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, including ants, amphibians and beetles; indolizidine alkaloids from the genera Polygonatum, Prosopis and Elaeocarpus; indolizidine and phenanthroindolizidine alkaloids; alkylquinolizidine alkaloids, including myrtine, epimyrtine, plumerinine and Lycopodium metabolites; Lythraceae and Nuphar alkaloids; lupine alkaloids; and alkaloids from marine sources. 150 references are cited.

摘要

本综述涵盖了吲哚里西啶和喹诺里西啶生物碱的分离、结构测定、合成、化学转化及生物活性。综述内容包括羟基化吲哚里西啶类化合物（如雀斑氨酸、苦马豆素、南美栗精胺及其类似物）；来自动物源的生物碱，包括蚂蚁、两栖动物和甲虫中的生物碱；来自黄精属、牧豆树属和杜英属植物的吲哚里西啶生物碱；吲哚里西啶和菲并吲哚里西啶生物碱；烷基喹诺里西啶生物碱，包括桃金娘碱、表桃金娘碱、鸡蛋花宁和石松属植物的代谢产物；千屈菜科和睡莲属生物碱；羽扇豆生物碱；以及来自海洋源的生物碱。文中引用了150篇参考文献。