Department of Chemistry and Comparative Medicine Institute, NC State University, Raleigh, North Carolina 27695, United States.
J Am Chem Soc. 2022 Jul 20;144(28):12638-12641. doi: 10.1021/jacs.2c06015. Epub 2022 Jul 5.
Indolizidine alkaloids have been the target of chemical and biological studies for decades, most recently highlighted by the isolation of the curvulamine and bipolamine polypyrrole-containing subclass. Herein we report a stereoselective 15-step synthesis of bipolamine I, a distinct member of the broader family, and through this work develop an intermediate that will serve to access other polypyrrole natural products and key analogues going forward.
吲哚里西啶生物碱数十年来一直是化学和生物学研究的目标,最近的研究热点是分离出含卷曲胺和双醇胺的多吡咯类生物碱。本文报道了双醇胺 I 的立体选择性 15 步全合成,双醇胺 I 是该大家族中的一个独特成员,通过这项工作开发出的中间体将用于获得其他多吡咯天然产物和关键类似物。