Shong Y K, Kim J A
Department of Internal Medicine, School of Medicine, University of Ulsan, Korea.
Thyroidology. 1991 May;3(2):89-91.
The authors studied the association between vitiligo and autoimmune thyroid disease. Vitiligo was found in 20 of 293 patients with autoimmune thyroid disease (6.83%), 2 out of 227 patients with nonautoimmune thyroid disease (0.88%), and 3 out of 386 control group (0.78%). These results showed that vitiligo is closely associated with autoimmune thyroid disease (chi 2 = 24.33, p < 0.0001), but not with nonautoimmune thyroid disease. Prevalence of vitiligo in nonautoimmune thyroid disease was not different from that in control. Vitiligo in autoimmune thyroid disease was most frequently found on dorsum hands and forearms, and usually preceded the onset of thyroid disease. Four out of twenty patients with vitiligo associated autoimmune thyroid disease had another presumed autoimmune disease, that is, alopecia areata, alopecia totalis, and rheumatoid arthritis. These findings suggested that autoimmunity plays an important role in the pathogenesis of vitiligo.
作者研究了白癜风与自身免疫性甲状腺疾病之间的关联。在293例自身免疫性甲状腺疾病患者中，有20例患有白癜风（6.83%）；在227例非自身免疫性甲状腺疾病患者中，有2例患有白癜风（0.88%）；在386例对照组中，有3例患有白癜风（0.78%）。这些结果表明，白癜风与自身免疫性甲状腺疾病密切相关（χ² = 24.33，p < 0.0001），但与非自身免疫性甲状腺疾病无关。非自身免疫性甲状腺疾病中白癜风的患病率与对照组无差异。自身免疫性甲状腺疾病中的白癜风最常见于手背和前臂，且通常在甲状腺疾病发病之前出现。20例白癜风合并自身免疫性甲状腺疾病的患者中有4例还患有另一种推测的自身免疫性疾病，即斑秃、全秃和类风湿关节炎。这些发现提示自身免疫在白癜风的发病机制中起重要作用。
