Higgins P D R, Leung J, Schwartz M, Mapili J, Wren P A, Zimmermann E M
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Aliment Pharmacol Ther. 2007 Feb 1;25(3):333-42. doi: 10.1111/j.1365-2036.2006.03205.x.
Ulcerative colitis disease activity indices have not been formally validated.
To analise quantitatively the psychometric and performance validity of two non-endoscopic indices for ulcerative colitis, the Simple Clinical Colitis Activity Index and the Seo Index.
In 66 patients with ulcerative colitis, the measurement of disease activity was repeated with the two non-endoscopic indices, St Mark's Index, and the Inflammatory Bowel Disease Questionnaire. Psychometric validity was evaluated by measuring the content, construct, criterion-convergent and criterion-predictive validity on a 0-1 scale. Performance validity was evaluated by measuring the reproducibility and responsiveness on a 0-1 scale.
The Simple Clinical Colitis Activity Index had good to excellent psychometric and performance validity, while the Seo Index had moderate to excellent psychometric validity and moderate to good performance validity. The Simple Clinical Colitis Activity Index had weaknesses in content validity and in responsiveness. The Seo Index had weaknesses in content validity, construct validity and responsiveness.
These two non-endoscopic indices for ulcerative colitis have good psychometric and performance validity, and are now the most rigorously validated disease activity indices for ulcerative colitis. The Simple Clinical Colitis Activity Index appears to have better overall validity. Quantitative evaluation identifies weaknesses in disease activity indices, and can lead to better disease activity indices for ulcerative colitis.
溃疡性结肠炎疾病活动指数尚未得到正式验证。
定量分析两种溃疡性结肠炎非内镜指数——简易临床结肠炎活动指数和徐氏指数的心理测量学及性能效度。
对66例溃疡性结肠炎患者，使用这两种非内镜指数、圣马克指数及炎症性肠病问卷重复测量疾病活动度。心理测量学效度通过在0 - 1量表上测量内容效度、结构效度、标准收敛效度和标准预测效度来评估。性能效度通过在0 - 1量表上测量可重复性和反应性来评估。
简易临床结肠炎活动指数具有良好至优秀的心理测量学及性能效度，而徐氏指数具有中等至优秀的心理测量学效度和中等至良好的性能效度。简易临床结肠炎活动指数在内容效度和反应性方面存在不足。徐氏指数在内容效度、结构效度和反应性方面存在不足。
这两种溃疡性结肠炎非内镜指数具有良好的心理测量学及性能效度，是目前溃疡性结肠炎最经过严格验证的疾病活动指数。简易临床结肠炎活动指数似乎具有更好的整体效度。定量评估可识别疾病活动指数中的不足，并能产生更好的溃疡性结肠炎疾病活动指数。
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