Studies on sex related differences in elimination of theophylline in the rat after pretreatment with phenobarbital, chrysene, Aroclor 1254 or lindane.

Cytochrome P-450 in liver microsomes plays a central role as a drug metabolizing enzyme. The sex-dependent differences in the properties of cytochrome P-450 have been extensively studied using liver microsomes, and marked differences have been found in microsomal metabolism of xenobiotic. Effect of pretreatment with phenobarbital, chrysene, lindane and polychlorinated biphenyls (Aroclor 1254) on the theophylline elimination in male and female rats was studied. Levels of theophylline were measured spectrophotometrically.