The influence of Aroclor 1254 on the elimination of theophylline in rats.

The commercial mixture of pollychlorinated biphenyls (Aroclor 1254) accelerates the elimination of theophylline (given iv and po) from the body of the rat. The increase in theophylline elimination rate by Aroclor 1254 depends on Aroclor 1254 dose and time of the dosing. Aroclor pretreatment reduced the amount of orally given theophylline in that reached the circulation by 17%. This was caused by the influence of Aroclor 1254 on the elimination rate and possible first-pass effect.