评估胃排空对口服葡萄糖耐量试验中测得的葡萄糖浓度-时间曲线形状的影响。
Estimation of influence of gastric emptying on shape of glucose concentration-time profile measured in oral glucose tolerance test.
作者信息
Dedík Ladislav, Durisová Mária, Penesová Adela, Miklovicová Daniela, Tvrdonová Martina
机构信息
Faculty of Mechanical Engineering, Slovak University of Technology, Slobody 17, 812 31 Bratislava, Slovak Republic.
出版信息
Diabetes Res Clin Pract. 2007 Sep;77(3):377-84. doi: 10.1016/j.diabres.2006.12.017. Epub 2007 Jan 30.
AIMS
To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems.
METHODS
Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration-time profiles of the subjects, the model was developed.
RESULTS
In all subjects the model was able to simulate influences of the insulin plasma concentration and gastric emptying rate on glucose concentration and to determine time profiles of glucose fractions retained in stomach.
CONCLUSIONS
The approach presented represents an opportunity for building models for data analyses in OGTT.
目的
使用动态系统理论工具开发一种用于模拟口服葡萄糖耐量试验（OGTT）过程的模型。
方法
对13名健康受试者（6名男性和7名女性）进行频繁采样的OGTT。随后，利用受试者的葡萄糖和胰岛素浓度-时间曲线，开发了该模型。
结果
在所有受试者中，该模型能够模拟胰岛素血浆浓度和胃排空率对葡萄糖浓度的影响，并确定保留在胃中的葡萄糖部分的时间曲线。
结论
所提出的方法为构建用于OGTT数据分析的模型提供了机会。
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