Martín M, Segalés J, Huang F F, Guenette D K, Mateu E, de Deus N, Meng X J
Departament de Sanitat i d'Anatomia Animals, Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
Vet Microbiol. 2007 May 16;122(1-2):16-24. doi: 10.1016/j.vetmic.2006.12.020. Epub 2007 Jan 3.
The aim of the study was to determine the presence of swine hepatitis E virus (HEV) RNA and antibodies in postweaning multisystemic wasting syndrome-affected (n=114) and non-affected (n=46) pigs and the possible association with hepatitis lesions. Forty-four pigs were RT-PCR positive (28.2%); 25 of them were PMWS cases, while 19 were non-PMWS pigs. In both groups, HEV RT-PCR results were associated with hepatitis (OR=5.61 for PMWS-affected pigs and OR=5.17 for non-PMWS affected pigs; p=0.01). No interaction was detected in a logistic regression between PMWS occurrence and HEV infection for the development of hepatitis lesions. Seropositivity to HEV was more likely to occur in pigs with hepatitis (51.9%) compared to pigs without hepatitis (36.1%; p=0.03). Significant differences in optical densities were notices comparing the lesional stage of pigs (p=0.009). While pigs with slight or moderate hepatitis were seropositive, pigs with more severe lesions were seronegative to HEV. These results indicate that swine HEV infection can be a significant contributor to the development of moderate hepatitis in pigs regardless of the PMWS status.
本研究的目的是确定断奶后多系统消耗综合征（PMWS）患病猪（n = 114）和未患病猪（n = 46）中猪戊型肝炎病毒（HEV）RNA和抗体的存在情况，以及与肝炎病变的可能关联。44头猪RT-PCR呈阳性（28.2%）；其中25头为PMWS病例，19头为非PMWS猪。在两组中，HEV RT-PCR结果均与肝炎相关（PMWS患病猪的OR = 5.61，非PMWS患病猪的OR = 5.17；p = 0.01）。在逻辑回归分析中，未检测到PMWS发生与HEV感染之间在肝炎病变发展方面存在相互作用。与无肝炎的猪相比，有肝炎的猪更易出现HEV血清阳性（51.9% 对36.1%；p = 0.03）。比较猪的病变阶段时，光密度存在显著差异（p = 0.009）。轻度或中度肝炎的猪血清呈阳性，而病变更严重的猪对HEV血清呈阴性。这些结果表明，无论PMWS状态如何，猪HEV感染可能是猪中度肝炎发展的一个重要因素。
