Murari Kartikeya, Thakor Nitish, Stanacevic Milutin, Cauwenberghs Gert
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Conf Proc IEEE Eng Med Biol Soc. 2004;2004:4063-6. doi: 10.1109/IEMBS.2004.1404134.
Neurotransmitter sensing is critical in studying nervous pathways and neurological disorders. A 16-channel current-measuring VLSI potentiostat with multiple ranges from picoamperes to microamperes is presented for electrochemical detection of electroactive neurotransmitters like dopamine, nitric oxide etc. The analog-to-digital converter design employs a current-mode, first-order single-bit delta-sigma modulator architecture with a two-stage, digitally reconfigurable oversampling ratio for ranging the conversion scale. An integrated prototype is fabricated in CMOS technology, and experimentally characterized. Real-time multi-channel acquisition of dopamine concentration in vitro is performed with a microfabricated sensor array.
神经递质传感对于研究神经通路和神经系统疾病至关重要。本文介绍了一种具有16个通道的电流测量型超大规模集成电路恒电位仪，其测量范围从皮安到微安，用于电化学检测多巴胺、一氧化氮等电活性神经递质。模数转换器设计采用电流模式、一阶单比特delta-sigma调制器架构，具有两级数字可重构过采样率，用于调整转换比例。采用CMOS技术制造了一个集成原型，并进行了实验表征。利用微纳加工传感器阵列对体外多巴胺浓度进行了实时多通道采集。
