Murari Kartikeya, Sauer Christian, Stanacevic Milutin, Cauwenberghs Gert, Thakor Nitish
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Conf Proc IEEE Eng Med Biol Soc. 2005;2005:7329-32. doi: 10.1109/IEMBS.2005.1616204.
Sensing neurotransmitters is critical in studying neural pathways and neurological disorders. An integrated device is presented which incorporates a potentiostat and a power harvesting and telemetry module. The potentiostat features 16 channels with multiple scales from microamperes to picoamperes. The wireless module is able to harvest power through inductively coupled coils and uses the same link to transmit data to and from the potentiostat. An integrated prototype is fabricated in CMOS technology, and experimentally characterized. Test results show RF powering introduces noise levels of 0.42% and 0.18% on potentiostat current scales of 500pA and 4nA respectively. Real-time multi-channel acquisition of dopamine concentration in vitro is performed with carbon fiber sensors.
感知神经递质对于研究神经通路和神经系统疾病至关重要。本文介绍了一种集成设备，它集成了一个恒电位仪以及一个能量收集和遥测模块。该恒电位仪具有16个通道，电流范围从微安到皮安，具有多个量程。无线模块能够通过电感耦合线圈收集能量，并使用同一链路在恒电位仪与外部之间传输数据。采用CMOS技术制造了一个集成原型，并进行了实验表征。测试结果表明，在恒电位仪500pA和4nA的电流量程上，射频供电分别引入了0.42%和0.18%的噪声水平。利用碳纤维传感器对体外多巴胺浓度进行了实时多通道采集。
