Drasler W J, Jenson M L, Wilson G J, Thielen J M, Protonotarios E I, Dutcher R G, Possis Z C
Possis Medical, Minneapolis, MN 55427.
Radiology. 1992 Jan;182(1):263-7. doi: 10.1148/radiology.182.1.1727293.
The authors present a percutaneous thrombectomy system (rheolytic thrombectomy catheter [RTC]) in which high-velocity jets of saline solution are used to lyse and remove thrombus. The catheters (4-6 F) direct a 10,000-15,000-psi (0.7-1.05 x 10(5)-kPa) jet of saline solution onto an exhaust port from orifices at the end of the catheter. The jet entrains clot and resulting fragments and brings them into the high-velocity region for lysis and removal. Whole blood clots (10-15 cm) placed in 6-9-mm-diameter tubing were completely dissolved and removed with the RTC in less than 1 minute. In vivo use in a canine model resulted in lysis and removal of clots from a femoral artery, without vessel damage. The small caliber, flexibility, and effective lysis of this system suggest its potential usefulness in large central vessels that are difficult to access surgically and in small-diameter vessels that require more rapid removal of thrombus than can be achieved with thrombolytic therapy.
作者介绍了一种经皮血栓切除术系统（溶栓血栓切除术导管[RTC]），该系统利用高速盐水射流来溶解和清除血栓。这些导管（4-6F）将10000-15000磅力/平方英寸（0.7-1.05×10⁵千帕）的盐水射流从导管末端的孔口导向一个排气口。该射流裹挟血块及其产生的碎片，并将它们带入高速区域进行溶解和清除。置于直径6-9毫米的管道中的全血血栓（10-15厘米）在不到1分钟的时间内被RTC完全溶解并清除。在犬类模型中的体内应用导致股动脉中的血栓溶解和清除，且没有血管损伤。该系统的小口径、柔韧性和有效溶解表明其在手术难以触及的大中心血管以及比溶栓治疗能更快清除血栓的小口径血管中具有潜在的应用价值。
