de Mesquita Júnior Jayme Alves, Lopes Agnaldo José, Jansen José Manoel, de Melo Pedro Lopes
Laboratory of Biomedical Instrumentation, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
J Bras Pneumol. 2006 May-Jun;32(3):213-20.
To evaluate the resistance values obtained through the use of the forced oscillation technique in patients with varying degrees of airway obstruction resulting from silicosis.
A total of 40 never-smoking volunteers were analyzed: 10 were healthy subjects with no history of pulmonary disease or silica exposure, and 30 had silicosis. The forced oscillation technique was used to examine the subjects, and spirometry was used as a reference in order to classify the obstruction by degree. This classification resulted in five groups: control (n = 10); normal exam, composed of individuals diagnosed clinically and radiologically with silicosis but presenting normal spirometry results (n = 7); mild obstruction (n = 10); moderate obstruction (n = 8); and severe obstruction (n = 5).
The reduction observed in the spirometric values corresponded to a significant increase in the total respiratory resistance (p < 0.001), as well as in airway resistance (p < 0.003). A significant reduction in ventilation homogeneity was also observed (p < 0.004).
In individuals with silicosis, the additional respiratory resistance-related data obtained through the use of the forced oscillation technique can complement spirometric data. Therefore, the forced oscillation technique presents great potential for the analysis of such patients.
评估通过强迫振荡技术在因矽肺导致不同程度气道阻塞的患者中获得的阻力值。
共分析了40名从不吸烟的志愿者：10名是无肺部疾病或二氧化硅接触史的健康受试者，30名患有矽肺。采用强迫振荡技术检查受试者，并以肺量计作为参考来按程度对阻塞进行分类。该分类产生了五组：对照组（n = 10）；正常检查组，由临床和放射学诊断为矽肺但肺量计结果正常的个体组成（n = 7）；轻度阻塞组（n = 10）；中度阻塞组（n = 8）；重度阻塞组（n = 5）。
观察到肺量计值的降低对应于总呼吸阻力的显著增加（p < 0.001）以及气道阻力的显著增加（p < 0.003）。还观察到通气均匀性显著降低（p < 0.004）。
在矽肺患者中，通过强迫振荡技术获得的与呼吸阻力相关的额外数据可以补充肺量计数据。因此，强迫振荡技术在分析此类患者方面具有巨大潜力。
