Rufino Rogério, Lapa e Silva José Roberto
Universidade Federal do Rio de Janeiro, School of Medicine, Rio de Janeiro, Rio de Janeiro, Brazil.
J Bras Pneumol. 2006 May-Jun;32(3):241-8.
Chronic obstructive pulmonary disease is an inflammatory disease. Together with oxidant stimuli, which directly affect lung structures, macrophages, neutrophils and CD8+ lymphocytes actively participate in the pathogenesis of the disease and promote biochemical reactions that result in progressive alteration of the upper airways and irreversible lung remodeling. The release of substances promoted by inflammatory cell recruitment and by oxidative stress lead to a temporary imbalance in the pulmonary defense mechanisms. Understanding the long-term maintenance of this imbalance is key to understanding the current physiopathology of the disease. The present study explores the cellular and molecular alterations seen in chronic obstructive pulmonary disease.
慢性阻塞性肺疾病是一种炎症性疾病。与直接影响肺结构的氧化应激刺激一起，巨噬细胞、中性粒细胞和CD8 +淋巴细胞积极参与该疾病的发病机制，并促进导致上呼吸道进行性改变和不可逆肺重塑的生化反应。炎症细胞募集和氧化应激促进的物质释放导致肺部防御机制暂时失衡。了解这种失衡的长期维持是理解该疾病当前病理生理学的关键。本研究探讨了慢性阻塞性肺疾病中所见的细胞和分子改变。
