Laffitte Emmanuel
Service de dermatologie et vénérologie, centre hospitalier universitaire vaudois, CH-IO11 Lausanne, Suisse.
Rev Prat. 2006 Nov 30;56(18):1977-83.
Thalidomide has several mechanisms of action: several immuno-modulatory properties, an anti-angiogenic action and a hypnosedative effect. Thalidomide has been used in several cutaneous inflammatory disorders (such as erythema nodosum leprosum in lepromatous leprosy, cutaneous lupus erythematosus, severe aphtosis), cancers (relapsed/refractory multiple myeloma) and inflammatory conditions. Several side effects are associated with thalidomide; some are major: teratogenicity, peripheral neuropathy and deep venous thrombosis; some are minor, such as somnolence or abdominal pain and endocrinologic disturbances. Use of thalidomide is strictly controlled with close adherence to a birth control program and close monitoring for early development of peripheral neuropathy.
具有多种免疫调节特性、抗血管生成作用和催眠镇静作用。沙利度胺已被用于多种皮肤炎症性疾病（如瘤型麻风的结节性红斑、皮肤红斑狼疮、严重口疮）、癌症（复发/难治性多发性骨髓瘤）及炎症性疾病。沙利度胺会引发多种副作用；有些较为严重：致畸性、周围神经病变和深静脉血栓形成；有些则较轻微，如嗜睡、腹痛和内分泌紊乱。沙利度胺的使用受到严格管控，需严格遵守避孕计划并密切监测周围神经病变的早期发展情况。
