通过铱催化的硼化反应和铜催化的偶联反应依次将芳烃转化为苯胺和芳基醚。
Arenes to anilines and aryl ethers by sequential iridium-catalyzed borylation and copper-catalyzed coupling.
作者信息
Tzschucke C Christoph, Murphy Jaclyn M, Hartwig John F
机构信息
Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520, USA.
出版信息
Org Lett. 2007 Mar 1;9(5):761-4. doi: 10.1021/ol062902w. Epub 2007 Feb 3.
[reaction: see text] N-Alkyl- and N-arylanilines were synthesized from arenes by a two-step sequence of iridium-catalyzed borylation and copper-catalyzed coupling with amines. Diaryl ethers were obtained by a related sequence of arene borylation, followed by coupling with phenols. In particular, 3,5-disubstituted arylamines and aryl ethers were prepared by initiating this sequence with meta-substituted arenes.
[反应：见正文] 通过铱催化的硼化和铜催化的与胺的偶联两步反应序列，从芳烃合成了N-烷基苯胺和N-芳基苯胺。通过芳烃硼化的相关反应序列，随后与酚偶联，得到了二芳基醚。特别地，通过以间位取代的芳烃引发该反应序列制备了3,5-二取代的芳胺和芳基醚。
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